An ovine transgenic Huntington's disease model

An ovine transgenic Huntington's disease model.

Huntington's disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by an expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene [Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. ...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Development of Transgenic Mice Harboring Ovine Beta Lactoglobulin-Calcitonin Transgene

Florid plaques in ovine PrP transgenic mice infected with an experimental ovine BSE.

The occurrence of the variant Creutzfeldt-Jakob disease (vCJD), related to bovine spongiform encephalopathy (BSE), raises the important question of the sources of human contamination. The possibility that sheep may have been fed with BSE-contaminated foodstuff raises the serious concern that BSE may now be present in sheep without being distinguishable from scrapie. Sensitive models are urgentl...

Prions of Ruminants Show Distinct Splenotropisms in an Ovine Transgenic Mouse Model

BACKGROUND Transmissible agents involved in prion diseases differ in their capacities to target different regions of the central nervous system and lymphoid tissues, which are also host-dependent. METHODOLOGY/PRINCIPAL FINDINGS Protease-resistant prion protein (PrP(res)) was analysed by Western blot in the spleen of transgenic mice (TgOvPrP4) that express the ovine prion protein under the con...